AstraZeneca is doing some really interesting research in this area - cell therapies that reset the immune system to eliminate the dysfunctional cells driving autoimmune disease, and then allow a healthy immune system to rebuild (for diseases like lupus, rheumatoid arthritis, and multiple sclerosis).
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jlukic
I’ve been on Tysabri for 3 years. I think anyone looking at this problem should just at the network meta analysis of outcomes from DMTs. You can think through each options risk profile, and then make a reasonable choice for your preferences. consensus.app is a good starting place for evaluating the research quickly.
if anyone needs to discuss i’d also be happy to share my experiences if you reach out.
ninju
should add [2021] to title (old article)
freezystem
https://neurosciencenews.com/gut-immune-responses-ms-trigger...
A landmark study from Keio University (published March 2026 in Science Immunology) has identified a key mechanism linking the gut to MS.
This opens the door to new MS treatments targeting the gut itself — such as modifying gut bacteria or blocking the abnormal antigen-presenting activity of IECs — rather than broadly suppressing the immune system
maxall4
I was part of a team researching MS at a university a while ago. It truly is an endlessly fascinating disease. Most evidence currently points to MS being caused by a combination of Epstein-Barr infection and genetic factors [0,1]. It is hypothesized that Epstein-Barr triggers autoimmunity which results in the prototypical demyelination [2].
- immune reset (sledgehammer that can “cure” diseases like MS but with many side effects and potential complications)
- immune suppression (super effective but with increased risk of infections and blunts vaccines)
- immune redirection (less effective but doesn’t mess up your immune system so badly).
It’s only in the last ~10 years that super effective treatments that can stop ~99% of lesion progression have existed- Ocrevus and Kesimpta. These are anti CD20 disease modifying therapies that destroy all your B cells. The memoir of Dr. Stephen Hauser- “The Face Laughs While The Brain Cries”- provides a fascinating insight into the development of these treatments over the last ~40 years of his career.
There are active trials of newer types of treatment and a lot of progress is being made in the MS space. It used to be a “death sentence” disease but is quite manageable for many sufferers now. It’s different for every individual and I wish the blog author good health.
functionmouse
Dead URL
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moralestapia
>First, a request: We do not wish to receive treatment or management advice for MS, including anything related to diet or lifestyle.
This, please. People tend to think that publishing a blog is some sort of "social" activity, a two-way conversation, a way to build/keep a small community. It is not, as a reader you're just expected to consume the content and move on; I hate when people overstep that boundary, jeez.
>How you can help
>We will continue to need your support.
>I’m sure we’re going to need help with things here and there. Running errands, taking care of things around the house, etc.
>Gift cards have been suggested as one way folks can lend a hand
Hey, this is great! Thank you for being very clear on what your needs are, that makes is so much easier to just reach out and help in a way that it wouldn't bother you. As you say gift cards are great because you don't even have to interact with the person sending it (COVID reasons), we can just send it to you, you receive it, if you're busy you don't even have to reply right away.
>We will communicate those requests as needed.
Thank you for the trust you put in us. I will remain pending of this, I can't wait to help.
https://www.astrazeneca.com/what-science-can-do/topics/next-...
AstraZeneca is doing some really interesting research in this area - cell therapies that reset the immune system to eliminate the dysfunctional cells driving autoimmune disease, and then allow a healthy immune system to rebuild (for diseases like lupus, rheumatoid arthritis, and multiple sclerosis).
I’ve been on Tysabri for 3 years. I think anyone looking at this problem should just at the network meta analysis of outcomes from DMTs. You can think through each options risk profile, and then make a reasonable choice for your preferences. consensus.app is a good starting place for evaluating the research quickly.
if anyone needs to discuss i’d also be happy to share my experiences if you reach out.
should add [2021] to title (old article)
https://neurosciencenews.com/gut-immune-responses-ms-trigger... A landmark study from Keio University (published March 2026 in Science Immunology) has identified a key mechanism linking the gut to MS. This opens the door to new MS treatments targeting the gut itself — such as modifying gut bacteria or blocking the abnormal antigen-presenting activity of IECs — rather than broadly suppressing the immune system
I was part of a team researching MS at a university a while ago. It truly is an endlessly fascinating disease. Most evidence currently points to MS being caused by a combination of Epstein-Barr infection and genetic factors [0,1]. It is hypothesized that Epstein-Barr triggers autoimmunity which results in the prototypical demyelination [2].
[0]: https://www.science.org/doi/10.1126/science.abj8222
[1]: https://www.pnas.org/doi/10.1073/pnas.2424986122
[2]: https://www.nature.com/articles/s41586-022-04432-7
MS treatments tend to take 3 forms:
- immune reset (sledgehammer that can “cure” diseases like MS but with many side effects and potential complications)
- immune suppression (super effective but with increased risk of infections and blunts vaccines)
- immune redirection (less effective but doesn’t mess up your immune system so badly).
It’s only in the last ~10 years that super effective treatments that can stop ~99% of lesion progression have existed- Ocrevus and Kesimpta. These are anti CD20 disease modifying therapies that destroy all your B cells. The memoir of Dr. Stephen Hauser- “The Face Laughs While The Brain Cries”- provides a fascinating insight into the development of these treatments over the last ~40 years of his career.
There are active trials of newer types of treatment and a lot of progress is being made in the MS space. It used to be a “death sentence” disease but is quite manageable for many sufferers now. It’s different for every individual and I wish the blog author good health.
Dead URL
>First, a request: We do not wish to receive treatment or management advice for MS, including anything related to diet or lifestyle.
This, please. People tend to think that publishing a blog is some sort of "social" activity, a two-way conversation, a way to build/keep a small community. It is not, as a reader you're just expected to consume the content and move on; I hate when people overstep that boundary, jeez.
>How you can help
>We will continue to need your support.
>I’m sure we’re going to need help with things here and there. Running errands, taking care of things around the house, etc.
>Gift cards have been suggested as one way folks can lend a hand
Hey, this is great! Thank you for being very clear on what your needs are, that makes is so much easier to just reach out and help in a way that it wouldn't bother you. As you say gift cards are great because you don't even have to interact with the person sending it (COVID reasons), we can just send it to you, you receive it, if you're busy you don't even have to reply right away.
>We will communicate those requests as needed.
Thank you for the trust you put in us. I will remain pending of this, I can't wait to help.